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Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM  WR Wiedemeyer, IF Dunn, SN Quayle… - Proceedings of the …, 2010 - National Acad Sciences Glioblastoma multiforme (GBM) is a fatal primary brain tumor harboring myriad genetic and epigenetic alterations. The recent multidimensional analysis of the GBM genome has provided a more complete view of the landscape of such alterations and their linked pathways. This effort has demonstrated that certain pathways are universally altered, but that the specific genetic events altered within each pathway can vary for each particular patient9s tumor. With this atlas of genetic and epigenetic events, it now becomes feasible to …