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Applications of DNA-based liquid biopsy for central nervous system neoplasms
J Wang, C Bettegowda - The Journal of Molecular Diagnostics, 2017 - Elsevier
The management of central nervous system malignancies remains reliant on histopathological analysis and neuroimaging, despite their complex genetic profile. The intratumoral heterogeneity displayed by these tumors necessitates a more sophisticated method of tumor analysis and monitoring, with the ability to assess tumors over space and time. Circulating biomarkers, including circulating tumor cells, circulating tumor DNA, and extracellular vesicles, hold promise as a type of real-time liquid biopsy able to provide …
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